Outer membrane channel protein of an oral pathogen binds human cytokine IL-8

Outer membrane channel protein of an oral pathogen binds human cytokine IL-8

Opportunistic pathogen Aggregatibacter actinomycetemcomitans resides in the multispecies biofilm in dento-gingival junction. A. actinomycetemcomitans binds and uptakes human proinflammatory cytokines, which may increase the bacterial virulence. Outer membrane secretin channel (here OMS), a DNA binder, is involved in uptake of DNA by A. actinomycetemcomitans. However, OMS homologue in Neisseria ...

A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin.

The antigenicity, structural location, and function of the predicted lipoprotein TP0136 of Treponema pallidum subsp. pallidum were investigated based on previous screening studies indicating that anti-TP0136 antibodies are present in the sera of syphilis patients and experimentally infected rabbits. Recombinant TP0136 (rTP0136) protein was purified and shown to be strongly antigenic during huma...

Human complement factor H binds to outer membrane protein Rck of Salmonella.

Serum resistance, or resistance to complement-mediated killing, is a key virulence property of microbial pathogens. Rck is a 17-kDa outer membrane protein encoded on the virulence plasmid of Salmonella enterica serovars Typhimurium and Enteritidis. When expressed in either Escherichia coli or S. enterica Typhimurium, Rck confers serum resistance independent of LPS length. Recently, the Rck homo...

Macrophages (OmpA) Binds to and Activates Human Cutting Edge: Outer Membrane Protein A

Molecular Investigation of Outer Membrane Channel Genes Among Multidrug Resistance Clinical Pseudomonas Aeruginosa Isolates

Background: Multidrug resistance Pseudomonas aeruginosa (MDRPA) is most important issue in healthcare setting. It can secrete many virulence effector proteins via its secretion system type (T1SS-T6SS). They are using them as conductor for delivering the effector proteins outside to begins harmful effect on host cell increasing pathogenicity, competition against other microorganism and nutrient ...